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Vaccine induced mumps-like diseases
Developments in Biological Standardization
|January 1, 1979
Abstract:
Sixteen cases of parotitis and 2 cases of diabetes mellitus after mumps vaccination have been reported since the introduction of the live attenuated mumps vaccine in the F. R. Germany in the fall of 1976. Due to the post-vaccination incubation of 7 to 10 days, support is given to the assumption that these cases are vaccine induced and not coincidental wild virus infections. The diabetes mellitus cases, however, are too few to be included in this rational.
Insights
Mumps vaccination may cause parotitis (mumps-like illness) in some individuals. The study suggests these cases are vaccine-induced due to the typical incubation period observed after vaccination.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- The live attenuated mumps vaccine was introduced in F. R. Germany in 1976.
- Post-vaccination adverse events require careful monitoring and analysis.
Purpose of the Study:
- To investigate potential adverse events following mumps vaccination.
- To determine if reported cases of parotitis and diabetes mellitus are linked to the vaccine.
Main Methods:
- Retrospective analysis of reported cases post-vaccination.
- Evaluation of the temporal relationship between vaccination and symptom onset.
Main Results:
- Sixteen cases of parotitis were reported after mumps vaccination.
- A 7-10 day incubation period supports a vaccine-induced etiology for parotitis.
- Two cases of diabetes mellitus were reported, but deemed insufficient for analysis.
Conclusions:
- The live attenuated mumps vaccine is associated with an increased risk of parotitis.
- Further investigation is needed for the potential link between mumps vaccine and diabetes mellitus.