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Success and failure of a rubella immunization programme.

T A Swartz, E B Porath, L Hornstein

    Developments in Biological Standardization
    |January 1, 1979
    PubMed
    Summary

    Israel

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    Area of Science:

    • Immunology
    • Epidemiology
    • Public Health

    Background:

    • A Rubella control program was initiated in Israel in 1973.
    • The program targeted schoolgirls and young females in communal settlements for immunization.

    Purpose of the Study:

    • To evaluate the effectiveness of a Rubella vaccination program.
    • To assess vaccination coverage, seroconversion rates, and population immunity levels.

    Main Methods:

    • Utilized HEP77DE5 and Wistar RA 27/3 (WI-38) Rubella vaccine strains.
    • Conducted a 5-year follow-up study including serological assessments.
    • Monitored Rubella incidence during a 1978 epidemic.

    Main Results:

    • Achieved 95% vaccination coverage with near 100% seroconversion.
    • Identified 15% of childbearing-aged females lacking Rubella HI antibodies.
    • Observed no cases in vaccinated individuals during a widespread epidemic in communal settlements.

    Conclusions:

    • The Rubella control program demonstrated high efficacy in vaccinated populations.
    • Residual population immunity gaps necessitate ongoing surveillance and vaccination strategies.
    • Targeted immunization significantly reduced Rubella transmission during an epidemic.

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