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Thyroid function in hemodialysis.

O Soffer, D Pelet, S Segal

    Israel Journal of Medical Sciences
    |October 1, 1979
    PubMed
    Summary
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    Hypothyroidism in hemodialysis patients is common, with many showing low thyroid hormone levels. Diagnosis should rely on free thyroxine index (FTI) and thyroid-stimulating hormone (TSH) for biochemical hypothyroidism.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Clinical Biochemistry

    Background:

    • The presence of hypothyroidism in patients undergoing regular hemodialysis is a subject of ongoing debate.
    • Thyroid dysfunction can significantly impact patient health and treatment outcomes.

    Purpose of the Study:

    • To assess various thyroid function indexes in patients on chronic hemodialysis.
    • To determine the prevalence and diagnostic criteria for hypothyroidism in this population.

    Main Methods:

    • Assessed thyroid function using multiple biomarkers including thyroxine, triiodothyronine (T3), T3-Sephadex binding, free thyroxine index (FTI), radioiodine uptake, and thyroid-stimulating hormone (TSH).
    • Studied a cohort of 46 patients undergoing chronic hemodialysis for 2 to 45 months.

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    Main Results:

    • Low serum thyroxine observed in 69.5% and low T3 in 46.5% of patients.
    • Abnormalities in FTI (26.3%) and elevated TSH (13.0%) were noted.
    • Overall hypothyroidism incidence, based on FTI and TSH, was 34.8%.

    Conclusions:

    • Diagnosis of hypothyroidism in hemodialysis patients should be primarily based on FTI and TSH levels.
    • Chronically hemodialyzed patients frequently present with biochemical hypothyroidism rather than overt clinical symptoms.