Jove
Visualize
Contact Us

Related Experiment Videos

Another example of a B variant.

A Simmons, J Twaitt

    Transfusion
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study reports a rare weak B variant in a family, likely due to a specific ABO gene allele. The findings shed light on blood group genetics and inheritance patterns.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cabozantinib plus nivolumab and ipilimumab in previously untreated, advanced renal cell carcinoma: final results and biomarker analyses from the phase III COSMIC-313 study.

    Annals of oncology : official journal of the European Society for Medical Oncology·2026
    Same author

    Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS).

    BMC cancer·2021
    Same author

    Current and emerging treatment strategies for hair loss in women of color.

    International journal of women's dermatology·2019
    Same author

    Communication Barrier in Family Linked to Increased Risks for Food Insecurity among Deaf Adults who use American Sign Language - CORRIGENDUM.

    Public health nutrition·2018
    Same author

    Altered fear processing in adolescents with a history of severe childhood maltreatment: an fMRI study.

    Psychological medicine·2018
    Same author

    Grey matter volume and thickness abnormalities in young people with a history of childhood abuse.

    Psychological medicine·2017
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Immunogenetics
    • Blood group serology
    • Human genetics

    Background:

    • The ABO blood group system is crucial for transfusion compatibility and understanding human genetic diversity.
    • Weak B phenotypes can arise from various genetic mutations affecting the B antigen expression.

    Observation:

    • A family exhibited a weak B phenotype, with five members showing weak B reactions and one showing normal A and weak B reactions.
    • Affected individuals displayed weak reactivity with anti-B sera but normal anti-A activity.
    • Absence of anti-B in sera and increased cellular H substance were noted in all tested members.

    Findings:

    • The weak B phenotype is attributed to the inheritance of a variant allele at the ABO locus.
    • Secretor members with the variant allele secreted normal amounts of B and H substances.

    Related Experiment Videos

  • Serum transferase activity confirmed the presence of the B-gene specific transferase, indicating functional B antigen production.

    • Implications:

    • This case provides insights into the genetic basis of rare blood group phenotypes.
    • Understanding weak B variants is essential for accurate blood typing and transfusion practices.
    • Further research can elucidate the specific molecular mechanisms underlying this ABO variant.