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Cell surface fibronectin and oncogenic transformation.

R O Hynes, A T Destree, M E Perkins

    Journal of Supramolecular Structure
    |January 1, 1979
    PubMed
    Summary
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    Cell surface fibronectin, a large glycoprotein, forms networks and is crucial for cell adhesion. Its reduction or absence in transformed cells correlates with increased tumor metastasis, impacting cell behavior.

    Area of Science:

    • Cell Biology
    • Biochemistry
    • Oncology

    Background:

    • Fibronectin is a large, dimeric glycoprotein found on cell surfaces and in plasma.
    • It forms extensive fibrillar networks, interacting with other macromolecules and intracellular microfilaments.
    • Cell surface fibronectin is often reduced or absent in transformed cells.

    Purpose of the Study:

    • To investigate the role of fibronectin in cell adhesion and transformation.
    • To explore the correlation between fibronectin levels and tumorigenicity, specifically metastatic ability.
    • To understand fibronectin's contribution to the altered cell behavior observed in the transformed phenotype.

    Main Methods:

    • Analysis of fibronectin expression in various cell types.
    • Correlation studies between fibronectin levels and tumorigenic/metastatic potential.

    Related Experiment Videos

  • Investigation of fibronectin's interactions with other cellular components.

    • Main Results:

    • Fibronectin forms cell surface and extracellular matrix networks, not typical membrane proteins.
    • Reduced or absent cell surface fibronectin correlates with increased tumorigenicity and metastatic ability in transformed cells.
    • Loss of fibronectin leads to decreased cell adhesion and pleiotropic alterations in cell behavior.

    Conclusions:

    • Fibronectin plays a critical role in cell adhesion and maintaining normal cell phenotypes.
    • Altered fibronectin expression is implicated in cancer progression, particularly metastasis.
    • Fibronectin's interactions are fundamental to cell structure and behavior, with implications for understanding the transformed phenotype.