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[Yersinia arthritis (author's transl)].

J D Herrlinger, H H Wuthe

    Medizinische Klinik
    |November 9, 1979
    PubMed
    Summary

    Yersinia arthritis presents as acute, painful joint inflammation, often affecting the knees and ankles. Diagnosis involves specific serum agglutination tests, with HLA-B27 antigen being a key factor in susceptibility.

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    Contributions to microbiology and immunology·1995

    Area of Science:

    • Rheumatology
    • Infectious Diseases
    • Immunology

    Background:

    • Yersinia enterocolitica infection can trigger reactive arthritis, a condition primarily affecting the joints.
    • Understanding the clinical presentation and diagnostic challenges of Yersinia-induced arthritis is crucial for timely management.

    Observation:

    • The study details three cases of Yersinia arthritis, characterized by acute oligoarthritis predominantly in the knee and ankle joints.
    • Affected joints exhibit significant pain, swelling, and warmth.
    • Patients may present with a history of enteritis or lower abdominal pain suggestive of appendicitis, though not always present.

    Findings:

    • Inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cell count are significantly elevated.
    • Diagnosis is confirmed via serum agglutination testing (Widal reaction) against Yersinia enterocolitica O-antigens.
    • A strong association exists between developing Yersinia arthritis and the presence of the Human Leukocyte Antigen (HLA) B27 antigen.

    Implications:

    • The findings highlight the importance of considering Yersinia infection in the differential diagnosis of acute arthritis, particularly in patients with relevant symptoms and HLA-B27 positivity.
    • Accurate diagnosis aids in appropriate treatment and can help differentiate from other inflammatory arthropathies.
    • Further research into the immunopathogenesis of Yersinia-induced reactive arthritis may reveal new therapeutic targets.

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