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Palliation in malignant pleural effusion.

L P Johnson, S E Rivkin, E L Weber

    The American Surgeon
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Intrapleural chemotherapy via thoracostomy offers effective palliation for malignant pleural effusion. Most patients experienced significant symptom relief, making it a preferred treatment for recurring effusions.

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    Area of Science:

    • Oncology
    • Pulmonology
    • Palliative Care

    Background:

    • Malignant pleural effusion is a common complication of various cancers.
    • Recurrent malignant pleural effusion significantly impacts patient quality of life.
    • Traditional thoracentesis provides only temporary relief.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intrapleural chemotherapy administered via thoracostomy for managing malignant pleural effusion.
    • To assess the palliative benefits and long-term outcomes in patients treated with this approach.

    Main Methods:

    • A cohort of 19 patients with malignant pleural effusion underwent thoracostomy and intrapleural chemotherapy.
    • Patients were monitored for response, duration of palliation, and survival.

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  • Technical aspects and indications for the procedure were reviewed.

    • Main Results:

    • Of 19 patients, 14 did not require further thoracentesis post-procedure.
    • The 14 surviving patients showed positive responses: 11 complete and 3 partial.
    • Palliation lasted from 1 to 28 months, indicating significant symptom control.

    Conclusions:

    • Intrapleural chemotherapy via thoracostomy is an effective treatment for malignant pleural effusion.
    • The procedure offers good palliation and can delay the need for repeat thoracentesis.
    • This method is recommended as a primary treatment for recurrent malignant pleural effusion.