Haloperidol-induced changes in the regional cerebral pharmacokinetics of apomorphine

Haloperidol did not change significantly the rate of penetration of apomorphine to three investigated structures of the rat brain: striatum, limbic forebrain and cerebellum. It depressed, however, significantly the accumulation of apomorphine in the striatum and limbic forebrain; in the cerebellum, in which the accumulation of apomorphine was very low, haloperidol did not change it. In haloperidol-pretreated rats the pattern of elimination of apomorphine from the striatum changed, revealing the presence of two compartments; this was not observed in the limbic forebrain, from which the elimination was linear, both in the presence and absence of haloperidol.