[Oral administration of insulin with synthetic polymers]

A saccharolytic action of insulin given orally with various synthetic polymers to rabbits was studied. Blood sugar level gave the greatest fall when insulin mixtures with strong electrolytes were used. In this case when the weight proportion of insulin-polymers was 1 : 5 insulin action was prolonged to 5 hours, addition of surfactants permitted to get an analogous saccharolytic effect with reduction of the insulin dose by half (50 AU per animal).