Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A comparison of six procedures for compatibility testing.

R M Greendyke, J C Banzhaf, J Inglis

    Transfusion
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Combined endoscopic approach for patients with multiple bladder stones.

    Annals of the Royal College of Surgeons of England·2015
    Same author

    Stochastic neural field equations: a rigorous footing.

    Journal of mathematical biology·2014
    Same author

    The Benevolent Fund.

    Provincial medical journal and retrospect of the medical sciences·2011
    Same author

    Case of Traumatic Tetanus.

    Provincial medical & surgical journal·2010
    Same author

    On Traumatic Tetanus and Its Treatment, with Some Remarks on the Extract of Cannabis Indica of Commerce.

    Provincial medical & surgical journal·2010
    Same author

    Differentiation of serrated and non-serrated blades from stab marks in bone.

    International journal of legal medicine·2008

    Low-ionic strength saline (LISS) combined with broad-spectrum antiglobulin testing (AGT) offers superior sensitivity for blood compatibility tests. This method is effective for routine antibody detection, even with shorter incubation times.

    Area of Science:

    • Transfusion Medicine
    • Immunology
    • Clinical Pathology

    Background:

    • Compatibility testing is crucial for preventing transfusion reactions.
    • Traditional methods may have limitations in sensitivity or require longer incubation periods.

    Purpose of the Study:

    • To compare the sensitivity and reliability of six different blood compatibility testing procedures.
    • To evaluate the efficacy of low-ionic strength saline (LISS) in combination with antiglobulin testing (AGT).

    Main Methods:

    • Red blood cells were sensitized using normal saline, albumin, or LISS.
    • Sensitized cells were tested with either broad-spectrum or anti-IgG AGT.
    • Six distinct compatibility testing procedures were evaluated.

    Related Experiment Videos

    Main Results:

    • LISS-based methods, particularly with broad-spectrum AGT, demonstrated high sensitivity, comparable to albumin methods.
    • LISS methods were more sensitive than other tested combinations.
    • No false positive results were observed across the evaluated procedures.

    Conclusions:

    • The LISS technique, especially when combined with broad-spectrum AGT, is a suitable and superior method for routine antibody detection and compatibility testing.
    • This approach offers enhanced sensitivity and reliability in pre-transfusion testing.