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Hemodialysis with glycerol dialysate
Transactions - American Society for Artificial Internal Organs
|January 1, 1979
Summary
Glycerol in hemodialysis fluid did not improve patient symptoms or vascular stability, unlike other solutes. Its distribution suggests benefits from extracellular agents like mannitol, sodium, and glucose.
Area of Science:
- Nephrology
- Renal Replacement Therapy
- Biochemistry
Background:
- Chronic hemodialysis can lead to complications like decreased serum osmolality and associated symptoms.
- Understanding solute distribution is crucial for optimizing dialysis fluid composition.
Purpose of the Study:
- To evaluate the efficacy of glycerol in preventing osmolality fall and improving patient outcomes during chronic hemodialysis.
- To compare glycerol's effects with other commonly used solutes in dialysis.
Main Methods:
- Patients undergoing chronic hemodialysis were treated with dialysate containing 36 mM glycerol.
- Serum osmolality, patient symptoms, and vascular stability were monitored.
Main Results:
- Glycerol at 36 mM prevented the drop in serum osmolality during hemodialysis.
- However, glycerol did not significantly decrease patient symptoms or improve vascular stability.
- These findings suggest glycerol's distribution differs from solutes that do improve outcomes.
Conclusions:
- Glycerol's distribution profile does not confer the symptomatic or vascular benefits observed with other agents.
- The benefits of mannitol, sodium, and glucose in dialysis may stem from their exclusive extracellular distribution.