Related Experiment Videos
Induction of hypothermia in mice by semi-artificial cells containing indolyl-3-alkane alpha-hydroxylase
Transactions - American Society for Artificial Internal Organs
|January 1, 1979
Abstract:
The administration of red cell ghost encapsulated indolyl-3-alkane alpha-hydroxylase (an enzyme which destroys tryptophan by oxidation of the side chains) in CD-1 female mice causes effective tryptophan depletion in plasma and brain and induces hypothermia by probably decreasing the serotonin concentration in brain by decreasing the concentration of its precursor, L-tryptophan.