[Antiviral activity of anomeric 5-substituted 2'-deoxyuridines]

T A Bektemirov, E V Chekunova, O G Andzhaparidze

|November 1, 1979

Abstract:

The inhibiting effect for herpes and vaccinia viruses of 2'-deoxyuridine derivatives containing the substitute in the position of 5-pyrimidine ring was studied. Anomeric 5-isopropyl-2'-deoxyuridines were shown to produce a marked inhibiting effect in chick embryo fibroblasts infected with herpes virus and to have no effect on vaccinia virus replication, that is, to be specific antiherpetic agents. The alpha-anomer of 5-isopropyl-2'-deoxyuridine showed antiherpetic activity in vitro comparable with that of beta-anomer. Fifty per cent toxic doses and chemotherapeutic indices of the drugs under study were determined in comparison with those of 5-iod-2'-deoxyuridine.

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Abstract:

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