[Unusual skin manifestation in undifferentiated cell leukemia]

In undifferentiated cell leukoses of adults cutaneous manifestations are relatively rare. Therefore the casuistics of a 20-year-old patient with a subleukaemic undifferentiated cell paraleukoblast leukosis is described which is characterized by a cutaneous manifestation in form of cherry-stone-sized papules, the leukotic genesis of which could be histologically ascertained. An initial cytostatic polychemotherapy with Vincristin, Alexan and Daunoblastin did not show any effect concerning the marrow conditions as well as the skin changes which still increased in size. An associated combination therapy with Methotrexat and Daunoblastin led to a diminution and paling of the skin infiltrations, which by a subsequent Methotrexat-monotherapy fully disappeared, apart from pigmented residual spots. In the bone marrow took place a full remission of the acute leukosis as certained by biopsy of the iliac crest.