Related Experiment Videos
Altered gentamicin distribution in ascitic patients.
American Journal of Hospital Pharmacy
|December 1, 1979
Summary
Gentamicin pharmacokinetics in ascites patients show significantly larger volumes of distribution (Vd). Dosage adjustments based on serum levels and clinical response are crucial for effective gentamicin therapy in these individuals.
Area of Science:
- Pharmacokinetics
- Nephrology
- Internal Medicine
Background:
- Ascites, characterized by abnormal extracellular fluid accumulation, can alter drug distribution.
- Understanding gentamicin pharmacokinetics is vital for optimizing treatment in patients with fluid imbalances.
Purpose of the Study:
- To investigate gentamicin pharmacokinetics in patients with ascites.
- To determine the impact of ascites on gentamicin volume of distribution (Vd).
Main Methods:
- Eight patients with ascites were included in the study.
- Gentamicin serum levels were measured using radioimmunoassay at various time points post-intravenous infusion.
- Volume of distribution (Vd) was calculated for each patient.
Main Results:
- The calculated Vd for gentamicin in patients with ascites was significantly larger compared to normal subjects (p < 0.025).
- Observed Vd values ranged from 20.2 to 53 liters.
- A poor correlation was found between Vd and patient body weights (lean and total).
Conclusions:
- Ascites significantly increases the volume of distribution for gentamicin.
- Gentamicin dosing in patients with ascites should be individualized, guided by serum drug level monitoring and clinical assessment.
- Adjusting dosage based on frequent serum gentamicin measurements is recommended for patients with abnormal fluid volumes.