Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxisuran metabolism in pigs.

M C Crew, F Di Carlo

    Drug Metabolism and Disposition: the Biological Fate of Chemicals
    |March 1, 1976
    PubMed
    Summary

    Oxisuran is rapidly absorbed and extensively metabolized in pigs, with most metabolites excreted in urine. Key biotransformations include reduction and oxidation, with limited Phase II conjugation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cannabis use disorder and dissociation: A report from a prospective first-episode psychosis study.

    Drug and alcohol dependence·2021
    Same author

    Consensus paper on postural dysfunction: recommendations for prevention, diagnosis and therapy.

    Journal of biological regulators and homeostatic agents·2021
    Same author

    Augmenting pharmacotherapy with neuromodulation techniques for the treatment of bipolar disorder: a focus on the effects of mood stabilizers on cortical excitability.

    Expert opinion on pharmacotherapy·2019
    Same author

    Mitotane treatment for adrenocortical carcinoma: an overview.

    Minerva endocrinologica·2012
    Same author

    Electrochemical behaviour of titanium in ammine and stannous fluoride and chlorhexidine 0.2 percent mouthwashes.

    International journal of immunopathology and pharmacology·2010
    Same author

    Influence of amine fluoride/stannous fluoride mouthwashes with and without chlorhexidine on secretion of proinflammatory molecules by peri-implant crevicular fluid cells.

    Minerva stomatologica·2008

    Area of Science:

    • Pharmacology
    • Drug Metabolism
    • Veterinary Science

    Background:

    • Understanding drug fate in livestock is crucial for efficacy and safety.
    • Oxisuran's metabolic pathways in pigs were previously uncharacterized.

    Purpose of the Study:

    • To investigate the biotransformation and disposition of oxisuran in pigs.
    • To identify oxisuran metabolites and their excretion routes.
    • To characterize the pharmacokinetics of oxisuran and its metabolites.

    Main Methods:

    • Utilized 14C-labeled oxisuran for quantitative analysis.
    • Studied drug absorption, biotransformation, and excretion in pigs.
    • Identified metabolites through chemical analysis.

    Main Results:

    • Oxisuran was rapidly absorbed and extensively biotransformed.
    • Metabolites were primarily excreted via urine, not feces.
    • Identified metabolic pathways included reduction and oxidation, forming sulfoxides and sulfones.
    • Phase II reactions, such as sulfation, were limited.

    Conclusions:

    • Oxisuran undergoes significant metabolism in pigs, primarily through Phase I reactions.
    • Urinary excretion is the main route for oxisuran metabolites.
    • Pharmacokinetic data provides insights into oxisuran's behavior in this species.

    Related Experiment Videos