Role of dopaminergic and GABA-ergic interactions in seizure susceptibility

The seizure susceptibility to electroshock in mice is decreased by apomorphine and piribedil; the effect of the two dopaminergic agonists is reduced by haloperidol. The seizure susceptibility is not influenced, increased or reduced by the different doses of haloperidol. The seizure threshold is elevated by amino-oxyacetic acid; its effect is reduced by picrotoxin, haloperidol and reserpine, and not influenced by apomorphine. The interaction between dopaminergic and GABA-ergic systems has been established; however, its characteristics are different from the well known interaction in the nigrostriatal region.