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Effect of premedication on etomidate anaesthesia
British Journal of Anaesthesia
|December 1, 1979
Summary
Premedication with fentanyl or diazepam before etomidate anesthesia reduced muscle movements during induction. However, fentanyl increased breathing pauses (apnoea), and neither premedication affected injection site pain.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Etomidate is an anesthetic induction agent.
- Involuntary muscle movements can occur during anesthetic induction.
- Premedication may influence anesthetic induction effects.
Purpose of the Study:
- To evaluate the effect of premedication on etomidate induction.
- To assess if premedication alters circulatory effects or muscle movements.
Main Methods:
- A study involving 74 adult patients undergoing elective orthopedic surgery.
- Patients received premedication with fentanyl plus atropine or diazepam plus atropine.
- Induction of anesthesia was performed using etomidate.
Main Results:
- Premedication with fentanyl or diazepam reduced involuntary muscle movements.
- Fentanyl premedication increased the frequency of apnoea (breathing pauses).
- Circulatory effects of etomidate were not modified by premedication.
Conclusions:
- Fentanyl and diazepam premedication can mitigate muscle movements during etomidate induction.
- Careful monitoring for apnoea is advised when using fentanyl premedication.
- Premedication does not alter etomidate's circulatory impact or injection site pain.