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Plasmalemmal and subsurface complexes in human leukemic cells: membrane bonding by zipperlike junctions
Science (New York, N.Y.)
|June 19, 1970
Summary
Monocytic cells in acute leukemia patients form unique membranous complexes after phagocytosis. These structures link cell membranes and pseudopodia, appearing in the cytoplasm.
Area of Science:
- Cell biology
- Hematology
- Oncology
Background:
- Phagocytosis is a critical cellular process.
- Acute leukemia affects monocytic cells.
- Membranous complexes are cellular structures with varied functions.
Purpose of the Study:
- To investigate the ultrastructural changes in monocytic cells from acute leukemia patients.
- To characterize novel membranous complexes formed after phagocytic stimulation.
Main Methods:
- Exposure of monocytic cells from acute leukemia patients to phagocytosis-inducing agents.
- Transmission electron microscopy to analyze cellular ultrastructure.
Main Results:
- Observed formation of pentalaminar and septate membranous complexes.
- These complexes were found connecting plasma membranes of adjacent cells.
- Complexes also observed joining pseudopodia surfaces on the same cell and in cortical cytoplasm.
Conclusions:
- Acute leukemia monocytic cells exhibit unique ultrastructural responses to phagocytic stimuli.
- The identified membranous complexes may play a role in cell-cell or cell-structure interactions.