Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypomagnesaemia in diabetes.

H M Mather, J A Nisbet, G H Burton

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |July 16, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Disappearing colorectal liver metastases in the era of state-of-the-art triple-modality diagnostic imaging.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2023
    Same author

    Reply to: Considerations on "impact of centralization of services on outcomes in a rare tumour: Retroperitoneal sarcomas".

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2019
    Same author

    European Society of Surgical Oncology's strategy for clinical research: Paving the way for a culture of research in cancer surgery.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2019
    Same author

    Impact of centralization of services on outcomes in a rare tumour: Retroperitoneal sarcomas.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2018
    Same author

    Precision surgery for colorectal liver metastases: Opportunities and challenges of omics-based decision making.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
    Same author

    PARAGON II - A single arm multicentre phase II study of neoadjuvant therapy using irinotecan bead in patients with resectable liver metastases from colorectal cancer.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2016
    Same journal

    Reference intervals for venous blood gas measurement in a healthy Chinese population.

    Clinica chimica acta; international journal of clinical chemistry·2026
    Same journal

    Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approach.

    Clinica chimica acta; international journal of clinical chemistry·2026
    Same journal

    Development and validation of patient-based exponentially weighted moving average quality control models for three antipsychotic drugs and their metabolites by LC-MS/MS.

    Clinica chimica acta; international journal of clinical chemistry·2026
    Same journal

    Comparing conventional correction formulas and machine learning-based prediction of ionized calcium.

    Clinica chimica acta; international journal of clinical chemistry·2026
    Same journal

    Micro- and nanoplastics as emerging clinical analytes: analytical validation, interpretive uncertainty, and laboratory actionability in human specimens.

    Clinica chimica acta; international journal of clinical chemistry·2026
    Same journal

    Performance of Free Light Chain reagents in the Dutch External Quality Assessment programme over the past 14 years.

    Clinica chimica acta; international journal of clinical chemistry·2026
    See all related articles

    Diabetic patients show significantly lower plasma magnesium levels compared to controls. This hypomagnesaemia may increase the risk of ischemic heart disease in individuals with diabetes.

    Area of Science:

    • Clinical Biochemistry
    • Endocrinology
    • Cardiovascular Disease

    Background:

    • Diabetes mellitus is a complex metabolic disorder associated with various complications.
    • Magnesium (Mg) plays a crucial role in numerous physiological processes, including glucose metabolism and cardiovascular health.
    • Alterations in plasma magnesium levels have been observed in various disease states.

    Purpose of the Study:

    • To investigate plasma magnesium concentrations in a cohort of diabetic outpatients.
    • To compare magnesium levels between diabetic patients and healthy control subjects.
    • To explore the relationship between plasma magnesium and clinical parameters in diabetes.

    Main Methods:

    • Plasma magnesium concentrations were measured using atomic absorption spectrophotometry.

    Related Experiment Videos

  • A cohort of 582 unselected diabetic outpatients and 140 control subjects were included.
  • Statistical analyses were performed to assess correlations and group differences.

    • Main Results:

    • Mean plasma magnesium was significantly lower in diabetic patients (0.737 +/- 0.071 mmol/l) than in controls (0.810 +/- 0.057 mmol/l).
    • Approximately 25% of diabetic patients exhibited plasma magnesium levels below the range of all control subjects.
    • Plasma magnesium showed a significant inverse correlation with blood glucose concentration (r = -0.32, p < 0.001) and associations with glycosuria, age, sex, and specific diabetes therapies (insulin, biguanides).

    Conclusions:

    • Diabetic patients exhibit significantly lower plasma magnesium levels compared to non-diabetic individuals.
    • Hypomagnesaemia in diabetes is associated with poorer glycemic control and other clinical factors.
    • Low plasma magnesium may be a contributing factor to the increased risk of ischemic heart disease observed in diabetic patients.