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Nickel sensitivity: relationship between history and patch test reaction.

M Kieffer

    Contact Dermatitis
    |December 1, 1979
    PubMed
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    Nickel sensitivity prevalence was studied in young adults using patch testing. History of metal contact or atopy does not reliably predict nickel sensitivity, highlighting the need for accurate diagnostic methods.

    Area of Science:

    • Dermatology
    • Allergology
    • Toxicology

    Background:

    • Nickel sensitivity is a common contact allergen.
    • Assessing nickel sensitivity historically can be unreliable.

    Purpose of the Study:

    • To determine the prevalence of nickel sensitivity in young adults.
    • To evaluate the predictive value of personal/family history of atopy and metal contact reactions for nickel sensitivity.

    Main Methods:

    • Patch testing with nickel sulfate 5% in petrolatum was performed on 415 young adults.
    • Participants completed a questionnaire regarding history of atopy and skin reactions to metals.

    Main Results:

    • Nickel sensitivity was identified in 2.8% of males and 9.8% of females.

    Related Experiment Videos

  • 13 of 28 individuals with a history of metal contact dermatitis showed negative patch test results for nickel.
  • 8 of 23 individuals with positive patch tests had no prior history of skin reactions to metals.

    • Conclusions:

    • Nickel sensitivity cannot be reliably predicted using pre-test historical information.
    • Patch testing remains crucial for diagnosing nickel sensitivity.