Respiratory disease in a colony of rats. I. The natural disease

Area of Science:

• Veterinary Pathology
• Microbiology
• Animal Health

Background:

• Acute respiratory disease outbreaks can significantly impact laboratory animal colonies.
• Mycoplasma infections are a known concern in rodent health.
• Understanding disease dynamics is crucial for maintaining research integrity.

Purpose of the Study:

• To describe an epidemic of acute respiratory disease in CFE rats.
• To record laboratory findings and discuss the etiology of the disease.
• To investigate the role of mycoplasma in rat respiratory illness.

Main Methods:

• Clinical observation of affected rats.
• Laboratory analysis of lung tissues.
• Identification of etiological agents.

Main Results:

• An epidemic of acute respiratory disease, ranging from peracute to chronic, was observed.
• Lung infection with a mycoplasma was associated with severe respiratory disease.
• Mycoplasmas were found in rats without disease signs, indicating other contributing factors.
• Rat strain differences in susceptibility to the disease were identified.

Conclusions:

• Mycoplasma infection is a key factor in severe rat respiratory disease.
• Co-factors likely play a role in the manifestation of mycoplasma-induced respiratory illness.
• Genetic susceptibility varies among rat strains, influencing disease outcomes.