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Oxalate loading test: a screening test for steatorrhoea.

D S Rampton, G P Kasidas, G A Rose

|December 1, 1979

Summary

This summary is machine-generated.

Urinary oxalate measurement during sodium oxalate loading can screen for steatorrhoea. This outpatient test is a reliable alternative to faecal fat excretion analysis for diagnosing malabsorption.

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Area of Science:

Gastroenterology
Clinical Chemistry
Diagnostic Medicine

Background:

Steatorrhoea, characterized by excessive faecal fat, is a key indicator of malabsorption.
Current diagnostic methods for steatorrhoea, such as faecal fat excretion tests, can be inconvenient for outpatients.
There is a need for a more accessible and reliable outpatient screening test for steatorrhoea.

Purpose of the Study:

To evaluate the efficacy of measuring urinary oxalate output as an outpatient screening test for steatorrhoea.
To compare urinary oxalate levels with faecal fat excretion in patients with suspected malabsorption.
To determine if oral sodium oxalate loading enhances the diagnostic capability of urinary oxalate measurement for steatorrhoea.

Main Methods:

32 patients with suspected malabsorption underwent assessment of 24-hour urinary oxalate and five-day faecal fat excretion.
Measurements were taken before and during an oral load of sodium oxalate (600 mg daily).
Patients consumed a controlled diet low in oxalate but adequate in fat and calcium.

Main Results:

Nineteen patients were diagnosed with steatorrhoea (mean faecal fat 62 mmol/24 h).
On a low oxalate diet, only nine patients with steatorrhoea showed elevated urinary oxalate.
With oral sodium oxalate loading, all 19 patients with steatorrhoea exhibited hyperoxaluria, with a significant positive correlation between urinary oxalate and faecal fat (r = 0.73, P < 0.001).
Mean absorption of oral oxalate was significantly higher in patients with steatorrhoea (14.7%) compared to normal subjects (5.8%).

Conclusions:

Urinary oxalate output measurement during oral sodium oxalate loading is a reliable and convenient outpatient screening test for steatorrhoea.
This method offers a practical alternative to faecal fat excretion tests for diagnosing malabsorption.
The increased absorption of oxalate in patients with steatorrhoea contributes to elevated urinary oxalate levels, making it a useful diagnostic marker.