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Physiological effects of increased tissue pressure.

F A Matsen, R V King, R B Krugmire

    International Orthopaedics
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    High tissue pressure severely impacts muscle blood flow and oxygen levels. Neuromuscular function decline occurs late, indicating circulatory deficiency is the primary issue in pressure injuries.

    Area of Science:

    • Physiology
    • Biomedical Engineering

    Background:

    • Increased tissue pressure can compromise local circulation and tissue viability.
    • Understanding the physiological response to elevated tissue pressure is crucial for managing various medical conditions.

    Purpose of the Study:

    • To investigate the physiological effects of elevated tissue pressure on hindlimb tissues in a rabbit model.
    • To determine the relationship between applied tissue pressure, muscle blood flow, tissue gas levels, and neuromuscular function.

    Main Methods:

    • Utilized a rabbit hindlimb model with controlled, uniform pressure application for 5 hours.
    • Employed an argon washout technique to monitor muscle blood flow.
    • Measured muscle oxygen (pO2), carbon dioxide (pCO2), and argon (pAr) using a catheter-mass spectrometer system.

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  • Assessed limb functional status via myoneural conduction velocity.

    • Main Results:

    • Elevated tissue pressures progressively reduced muscle blood flow and pO2.
    • Significant decrease in myoneural conduction velocity was observed only at 80 mm Hg.
    • At 80 mm Hg, muscle blood flow and pO2 reached zero, indicating complete circulatory arrest.

    Conclusions:

    • Neuromuscular function impairment is a late consequence of pressure-induced circulatory compromise.
    • Early detection and management of pressure injuries should focus on circulatory and tissue oxygenation status.