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Tissue ascorbic acid, fenfluramine, and changes in fat metabolism.

A Odumosu, C W Wilson

International Journal of Obesity

|January 1, 1979

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Vitamin C supplementation counteracts fenfluramine

Area of Science:

Biochemistry
Nutrition
Pharmacology

Background:

Scurvy, a deficiency in vitamin C (ascorbic acid), affects metabolism.
Fenfluramine is an appetite suppressant with known effects on weight and lipid metabolism.
The interaction between vitamin C status and fenfluramine's effects is not well understood.

Purpose of the Study:

To investigate the impact of fenfluramine on scorbutic guinea pigs.
To determine the effect of vitamin C supplementation on fenfluramine's actions in guinea pigs.

Main Methods:

Induction of scurvy in guinea pigs by vitamin C withdrawal.
Administration of fenfluramine to scorbutic and vitamin C-supplemented guinea pigs.
Monitoring of body weight, appetite, and hepatic levels of ascorbic acid, cholesterol, and triglycerides.

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Main Results:

Scorbutic guinea pigs exhibited reduced appetite and weight loss, with increased hepatic cholesterol.
Fenfluramine exacerbated weight loss and appetite reduction in scorbutic guinea pigs.
Vitamin C supplementation reversed fenfluramine's anorectic and weight-loss effects and reduced hepatic cholesterol and triglycerides.

Conclusions:

Vitamin C deficiency potentiates the adverse effects of fenfluramine on weight and appetite.
Vitamin C supplementation inhibits the anti-obesity and anorectic effects of fenfluramine.
Ascorbic acid plays a role in modulating fenfluramine's impact on lipid metabolism.