Pharmacokinetic study of a new semisynthetic cephalosporin (AL-226) in rabbits

The pharmacokinetics of AL-226, a new semi-synthetic cephalosporin, were studied after i.v. and i.m. administrations to rabbits at doses of 10, 20, 30 and 40 mg/kg. The average values of the pharmacokinetic parameters after bolus i.v. administration of the antibiotic expressed by an open two-compartment kinetic model were: alpha = 0.131 min.-1, beta = 0.0341 min-1, K12 = 0.0287 min.-1, K21 = 0.0552 min.-1, K13 = 0.081 min.-1 a linear relationship between C0 and dose was found. The urinary excretion constants after i.v. administration were: 0.0266 min.-1, 0.0294 min-1, 0.0289 min.-1, 0.0306 min.-1, for doses of 10, 20, 30 and 40 mg/kg, respectively. The pharmacokinetic parameters after i.v. administration were used to determine the absorption constant: 0.0525 min.-1, 0.057 min.-1, 0.0596 min.-1, 0.0511 min.-1, after i.m. administration for doses of 10, 20, 30 and 40 mg/kg, respectively.