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Virus-like particles induced by bromodeoxyuridine in melanoma and neuroblastoma of Xiphophorus
Journal of Cancer Research and Clinical Oncology
|January 1, 1979
Abstract:
5-Bromodeoxyuridine (BrdUrd) injected into the muscular tissue of fish bearing melanoma or neuroblastoma induces the production of virus-like particles in these tumors. The particles in the melanoma are morphologically similar to papovaviruses of polyoma-type, those in the neuroblastoma resemble oncornaviruses of B- and C-type.
Insights
Injecting 5-Bromodeoxyuridine (BrdUrd) into fish tumors stimulated virus-like particle production. Melanoma tumors produced polyoma-type particles, while neuroblastomas yielded oncornaviruses.
Area of Science:
- Oncology
- Virology
- Fish biology
Background:
- Fish can develop tumors like melanoma and neuroblastoma.
- The role of viral agents in fish tumor development is an area of ongoing research.
Purpose of the Study:
- To investigate the effect of 5-Bromodeoxyuridine (BrdUrd) on virus-like particle production in fish tumors.
- To characterize the morphology of induced virus-like particles in melanoma and neuroblastoma.
Main Methods:
- Administration of 5-Bromodeoxyuridine (BrdUrd) into the muscular tissue of fish.
- Tumor sampling from fish bearing melanoma or neuroblastoma.
- Morphological analysis of virus-like particles using electron microscopy.
Main Results:
- 5-Bromodeoxyuridine (BrdUrd) injection induced virus-like particle production in both melanoma and neuroblastoma.
- Particles from melanoma were morphologically similar to papovaviruses (polyoma-type).
- Particles from neuroblastoma resembled oncornaviruses (B- and C-type).
Conclusions:
- 5-Bromodeoxyuridine (BrdUrd) can act as a stimulus for endogenous viral particle production in fish tumors.
- The type of virus-like particle induced appears to correlate with the tumor type (melanoma vs. neuroblastoma).
- This suggests potential etiological links between specific virus types and fish neoplasms.