Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.3K
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

3.3K
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
3.3K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Papillary Dermis01:11

Papillary Dermis

6.3K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.3K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Translated article] Approach and management of patients injured by bullfighting trauma.

Revista espanola de cirugia ortopedica y traumatologiaยท2024
Same author

Approach and management of patients injured by bullfighting trauma.

Revista espanola de cirugia ortopedica y traumatologiaยท2024
Same author

The role of single nucleotide variant rs3819817 of the Histidine Ammonia-Lyase gene and 25-Hydroxyvitamin D on bone mineral density, adiposity markers, and skin pigmentation, in Mexican population.

Journal of endocrinological investigationยท2023
Same author

Pigmentary mosaicism as a recurrent clinical manifestation in three new patients with mosaic trisomy 12 diagnosed postnatally: cases report and literature review.

BMC medical genomicsยท2022
Same author

Polymorphisms CYP2R1 rs10766197 and CYP27B1 rs10877012 in Multiple Sclerosis: A Case-Control Study.

Journal of immunology researchยท2022
Same author

Treatment of esophageal perforation: A review of our experience at a tertiary referral hospital spanning the past 19 years.

Revista de gastroenterologia de Mexico (English)ยท2021

Related Experiment Video

Updated: Feb 26, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

749

Localized acquired cutaneous pseudoxanthoma elasticum.

K H Neldner, A Martinez-Hernandez

    Journal of the American Academy of Dermatology
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Localized acquired cutaneous pseudoxanthoma elasticum is a nonheritable skin condition. It presents with skin lesions similar to inherited pseudoxanthoma elasticum (PXE) but without associated eye or vascular issues.

    More Related Videos

    Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
    06:15

    Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

    Published on: August 9, 2024

    1.9K
    Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
    06:36

    Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

    Published on: May 1, 2019

    7.5K

    Related Experiment Videos

    Last Updated: Feb 26, 2026

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
    05:39

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

    Published on: May 16, 2025

    749
    Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
    06:15

    Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

    Published on: August 9, 2024

    1.9K
    Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
    06:36

    Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

    Published on: May 1, 2019

    7.5K

    Area of Science:

    • Dermatology
    • Genetics
    • Pathology

    Background:

    • Pseudoxanthoma elasticum (PXE) is typically an inherited disorder affecting connective tissues.
    • The inherited form is characterized by skin, retinal, and vascular abnormalities.

    Observation:

    • A novel designation, localized acquired cutaneous pseudoxanthoma elasticum, is proposed for a nonheritable variant.
    • This variant presents with skin lesions clinically, histologically, and ultrastructurally resembling inherited PXE.
    • A case study details a patient with lesions localized to the chest and abdomen.

    Findings:

    • The acquired form lacks the systemic stigmata (retinal and vascular) seen in inherited PXE.
    • Cases in the literature include idiopathic occurrences, particularly in multiparous Black females.
    • Some cases are linked to cutaneous exposure to calcium salts.

    Implications:

    • This distinction aids in diagnosing and understanding PXE variants.
    • Recognizing the acquired form is crucial for appropriate patient management and genetic counseling.
    • Further research into the pathogenesis of acquired PXE is warranted.