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Correlation of platelet taurine levels with thyroid function.

S I Baskin, S J Klekotka, Z V Kendrick

    Journal of Endocrinological Investigation
    |July 1, 1979
    PubMed
    Summary
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    Thyroid disease impacts behavior, potentially linked to neurotransmitters. This study found taurine levels in platelets correlate with thyroid status, suggesting a role for taurine in thyroid-related neurological changes.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Biochemistry

    Background:

    • Neurotransmitter and neuromodulator alterations are implicated in thyroid disease-related behavioral changes.
    • Taurine, a potential inhibitory neurotransmitter, was investigated as a marker in platelets, which can model synaptosomes.

    Purpose of the Study:

    • To explore the relationship between taurine levels in platelets and thyroid disease states (euthyroid, hypothyroid, hyperthyroid).
    • To assess the effect of treatments on this relationship.

    Main Methods:

    • Blood samples from euthyroid, hypothyroid, and hyperthyroid patients were analyzed for thyroxine levels (RIA).
    • Platelets were isolated via differential centrifugation.
    • Platelet taurine was quantified using ion exchange chromatography and spectrophotometry.

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    Main Results:

    • An inverse relationship between taurine/platelet and platelet count was observed in hypothyroid, untreated hyperthyroid, and euthyroid individuals.
    • This inverse relationship was absent in propranolol-treated hyperthyroid patients.
    • Platelet taurine levels normalized to euthyroid levels after treatment with antithyroid drugs and/or propranolol, despite persistent high thyroxine.

    Conclusions:

    • Platelet taurine levels are significantly associated with the thyroid state in humans.
    • Taurine may play a role in the pathophysiology of thyroid-related behavioral and neurological alterations.