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A novel closed-circular mitochondrial DNA with properties of a replicating intermediate

H Kasamatsu, D L Robberson, J Vinograd

Proceedings of the National Academy of Sciences of the United States of America

|September 1, 1971

Abstract:

A fraction of the covalently closed mitochondrial DNA in mouse L cells contains a replicated heavy-strand segment that is hydrogen bonded to the circular light strand. The inserted single strand is dissociable from the circular duplex at an elevated temperature.

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