Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The elastomeric rack in biology.

H Eyring, F H Johnson

Proceedings of the National Academy of Sciences of the United States of America

|October 1, 1971

Summary

This summary is machine-generated.

The elastomeric rack model explains enzyme catalysis by showing how protein conformational changes increase substrate-enzyme reactivity. This model accounts for environmental influences on protein catalysts and their physiological roles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Puberty and Menapause.

Atlanta journal-record of medicine·2022

Same author

On the Localized Causes of Cholera.

The Sanitary review and journal of public health·2018

Same author

Molecular mechanisms in inflammation and stress.

Science in progress·2014

Same author

The relation of ph and quinine to growth and disinfection rates of Escherichia coli.

Journal of bacteriology·2010

Same author

The rate of growth and disinfection of Escherichia coli in relation to temperature, hydrostatic pressure, and quinine.

Journal of bacteriology·2010

Same author

Studies on the nature of antibodies produced in vitro from bacteria with hydrogen peroxide and heat.

Journal of bacteriology·2010

Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026

See all related articles

Area of Science:

Biochemistry
Biophysics
Enzymology

Background:

Enzyme catalysis relies on large protein molecules.
The "Rack mechanism" provides a foundation for understanding enzyme function.
Experimental evidence shows significant volume changes in biochemical reactions.

Purpose of the Study:

Introduce and elaborate on the "elastomeric rack" model.
Explain how protein conformational changes enhance enzyme activity.
Account for environmental factors affecting protein catalysts.

Main Methods:

Utilizing hydrostatic pressure to study reaction rates and equilibria.
Analyzing experimental data on volume changes during biochemical processes.
Extending the "Rack mechanism" based on new evidence.

Related Experiment Videos

Main Results:

Demonstrated large volume changes in activation and reaction.
Confirmed significant protein conformational changes under pressure.
Established a link between protein structure, stress, and increased reactivity.

Conclusions:

The elastomeric rack model explains enzyme catalysis via protein conformational changes and stress.
The model accounts for environmental influences on protein catalyst activity.
This mechanism has implications for various physiological processes and diseases.