Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of a streptococcal preparation on the complement system.

H Kato, N Yokoe, N Matsumura

    The Japanese Journal of Experimental Medicine
    |October 1, 1979
    PubMed
    Summary

    Streptococcal preparation OK-432 (Picibanil) boosts host immunity by increasing serum complement levels, particularly C3, and activating complement pathways. This immunopotentiator shows promise in enhancing immune responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adenosine A2 receptor antagonist facilitates the reversal of long-term potentiation (depotentiation) of evoked postsynaptic potentials but inhibits that of population spikes in hippocampal CA1 neurons.

    Neuroscience letters·1992
    Same author

    The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

    The Journal of biological chemistry·1992
    Same author

    Immunohistochemical study of the histogenesis of esophageal carcinosarcoma.

    Japanese journal of clinical oncology·1992
    Same author

    Structure and distribution of the lymphatic vessels in the parietal pleura of the monkey as studied by enzyme-histochemistry and by light and electron microscopy.

    Archives of histology and cytology·1992
    Same author

    Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system.

    Brain research. Molecular brain research·1992
    Same author

    A hyperpolarizing response induced by glutamate in mouse cerebellar Purkinje cells.

    Neuroscience research·1992

    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • Streptococcal preparation OK-432 (Picibanil) is a clinically used immunopotentiator.
    • OK-432 is known to activate the complement system in vitro via classical or alternative pathways.

    Purpose of the Study:

    • To investigate the effect of OK-432 on serum complement levels in vivo.
    • To identify specific complement components affected by OK-432 administration.

    Main Methods:

    • Hemolytic assays were performed using sensitized sheep erythrocytes (EA) for classical pathway and unsensitized rabbit erythrocytes (RaE) for alternative pathway.
    • Serum complement levels and specific complement components (C3, C1q, C4, C5, C9, properdin, C3 activator, C1-inhibitor) were analyzed.

    Main Results:

    • OK-432 increased overall serum complement levels in guinea pigs and humans without malignancy.

    Related Experiment Videos

  • A significant increase in C3 and a decrease in C1q were observed.
  • No significant changes were noted in C4, C5, C9, properdin, C3 activator, or C1-inhibitor.

    • Conclusions:

    • OK-432 administration elevates serum complement levels, suggesting a mechanism for potentiating host immune responses.
    • The observed changes in C3 and C1q indicate a specific modulation of the complement system by OK-432.