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Proteinuria in the exercising dog.
Medicine and Science in Sports
|January 1, 1979
Summary
Heavy exercise can cause transient proteinuria in dogs, even when renal blood flow remains constant. This suggests that reduced renal blood flow is not the sole cause of exercise-induced proteinuria.
Area of Science:
- Nephrology
- Exercise Physiology
- Veterinary Medicine
Background:
- Exercise proteinuria is a temporary condition observed in humans after strenuous physical activity.
- It is widely believed that a decrease in renal blood flow (RBF) during exercise contributes to exercise proteinuria in humans.
Purpose of the Study:
- To investigate the occurrence of exercise proteinuria in dogs.
- To determine if exercise proteinuria can happen independently of changes in renal blood flow (RBF).
Main Methods:
- Four female mongrel dogs were surgically fitted with chronic bladder cannulas.
- Urine samples were collected from both kidneys before, during, and after 30 minutes of intense treadmill exercise (5 mph, 15% grade).
- Urine protein concentration was measured using the biuret method.
Main Results:
- Urine protein concentration significantly increased by 47% during exercise compared to resting levels (P < .01).
- Urine flow rate decreased during exercise, but protein excretion showed only a small, non-significant decline.
- Post-exercise urine protein concentration was significantly elevated compared to resting values (P < .01).
Conclusions:
- Exercise proteinuria can occur in dogs even when renal blood flow does not change significantly.
- These findings challenge the notion that reduced renal blood flow is the primary driver of exercise-induced proteinuria.