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Related Experiment Videos

Transsphenoidal meningocele with hypothalamic insufficiency.

J L Larsen, H H Bassøe

    Neuroradiology
    |October 31, 1979
    PubMed
    Summary

    A rare transsphenoidal meningocele case highlights hormonal disturbances in a 16-year-old girl. This emphasizes the need for thorough hormonal investigation in skull base dysraphism and cleft palate patients.

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    Endocrine·2010

    Area of Science:

    • Pediatric Endocrinology
    • Neurosurgery
    • Radiology

    Background:

    • Transsphenoidal meningocele is a rare congenital condition involving herniation of meninges through the sphenoid bone.
    • Hypothalamic insufficiency can result from structural abnormalities at the skull base.
    • Hormonal disturbances associated with this condition are infrequently reported.

    Observation:

    • A 16-year-old female presented with a transsphenoidal meningocele and clinical signs of hypothalamic insufficiency.
    • Radiological evaluation was crucial for diagnosis and differential diagnosis from persistent cranipharyngeal canal.
    • Literature review revealed only three previously reported similar cases.

    Findings:

    • The case underscores the association between transsphenoidal meningocele and hormonal imbalances.
    • Radiological criteria are essential for accurate diagnosis and distinguishing from other skull base anomalies.
    • Hormonal disturbances may be more common in these patients than previously thought.

    Implications:

    • Patients with signs of skull base dysraphism require comprehensive hormonal assessment.
    • Children diagnosed with cleft palate should be screened for potential concomitant skull base dysraphism.
    • Early detection and management of hormonal deficiencies are critical for long-term health outcomes.

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