Beta adrenergic stimulant suppression of efferent activity of the adrenal nerve

Efferent activity was recorded from nerve filaments dissected from the sympathetic nerve branches to the adrenal gland (adrenal nerve). An infusion of isoproterenol into the carotid artery suppressed the discharge of the adrenal nerve as did an equal dose of epinephrine whereas systemic blood pressure descended after isoproterenol injection. The beta blocking agent inhibited the suppression after epinephrine and isoproterenol application. The results suggest the existence of reflex inhibition of adrenal nerve activity through beta adrenergic receptors besides that of baroreceptors.