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Lophozozymus pictor toxin: a potent inhibitor of synaptosomal GABA uptake
Neuroscience Letters
|October 1, 1979
Abstract:
A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a GABA concentration of 2 microM. The inhibition showed substrate competition.