[Disodiumcromoglycate and histamine liberation by cotton dust extract in the rat (author's transl)]

1. Disodiumcromoglycate (DSCG) had no influence on the microscopical appearance of rat peritoneal mast cells either by i.p. injection (2 times 10(-5) g/ml) or by i.v. infection (10 mg/kg) nor by local application (2 times 10(-5)/1 times 10(-4) g/ml). 2. A particular effect of DSCG (2 times 10(-6)/2 times 10(-5) on the tonus of guinea pig ileum or an interaction with contractor activity due to histamine (3 times 10(-8)/1 times 10(-7) g/ml) has not been established. 3. Histamine liberation from rat peritoneal mast cells by i.p. injection of aqueous cotton dust extract was not inhibited by DSCG (2 times 10(-8)/2 times 10(-7) g/ml), histamine liberation was rather increased.