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[Newborn cardiotoxicity after tocolysis with fenoterolhydrobromide]
Padiatrie Und Padologie
|January 1, 1979
Summary
Long-term maternal use of Fenoterol for premature birth may cause cardiac complications in newborns, including arrhythmias and heart failure. These effects normalized within 8 weeks, but caution is advised with catecholamine derivatives.
Area of Science:
- Neonatal cardiology
- Pharmacology
- Obstetrics
Context:
- Sympathomimetic amines, like Fenoterol, are used to prevent premature birth.
- Maternal administration of Fenoterol (Partusisten) was studied in relation to neonatal outcomes.
- 30 newborns exposed to long-term maternal Fenoterol treatment were analyzed.
Purpose:
- To report clinical findings in newborns following maternal Fenoterol treatment.
- To investigate potential cardiotoxic effects of Fenoterol in neonates.
- To correlate clinical and electrocardiographic (ECG) findings.
Summary:
- Neonates exhibited tachycardia, dyspnea, cyanosis, metabolic acidosis, and congestive heart failure.
- ECG and vectorcardiogram (VCG) showed cardiac arrhythmias and T-wave inversions.
- Histological findings in deceased infants included polyploid cells and myocardial fatty degeneration, suggesting possible cardiotoxicity.
Impact:
- Fenoterol treatment in pregnancy may lead to transient neonatal cardiac complications.
- High-dose intravenous Fenoterol might cause myocardial issues.
- Catecholamine derivatives require cautious clinical application during pregnancy.