[Immunopathology of a model inflammation]

A series of 32 healthy individuals has been examined, in whom a large number of model inflammatory lesions of the "skin window" type had been produced. Physiological salina solution and diptheriac toxoid were administered by dropping as well as by intradermal injection into the lesioned areas of these individuals. The cover slips were removed after 12, 24 and 48 hours. The control inflammation without antigenic stimulation was characterized by the presence of neutrophilic granulocytes, monocytogenic macrophages and, later, also by epitheloid cells and foreign body giant cells. Celluization of the immune conditioned inflammation mainly consisted of rather small mononuclear cells related to the lymphatic series on the basis of their morphological and cytochemical features. In addition, neutrophils were also found, as well as typical macrophages, epitheloid and foreign body gaint cells. In the 24 and 48 hour preparations, particularly in those obtained from lesions following intradermal antigen administration, basophilic and eosinophilic granulocytes were a regular finding. The ftndings show a variability of the mutual proportions of immunocompetent and immunoneutral cells in the inflammatory cellulization under various condition.