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Related Experiment Videos

Methadone depression of visual signal detection performance.

S Rothenberg, E A Peck, S Schottenfeld

    Pharmacology, Biochemistry, and Behavior
    |November 1, 1979
    PubMed
    Summary

    Methadone slows reaction time by reducing visual sensitivity in a dose-dependent manner. This effect on visual function is linked to the central nervous system and parallels the drug

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Ophthalmology

    Background:

    • Oral methadone administration has been linked to slowed simple visual reaction time.
    • The precise mechanism underlying this visual performance deficit requires elucidation.

    Purpose of the Study:

    • To investigate the origin of methadone-induced visual reaction time slowing.
    • To differentiate between changes in visual sensitivity and response bias caused by methadone.

    Main Methods:

    • A modified double flash detection task was employed with three subjects.
    • Single doses of 5 mg and 10 mg oral methadone and placebo were administered.
    • Signal detection theory analysis was utilized to assess visual sensitivity and response bias.
    • Visual evoked potentials were recorded to evaluate neural responses to visual stimuli.

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    Main Results:

    • Methadone significantly reduced visual sensitivity in a dose-dependent manner.
    • The duration and peak of performance depression correlated with methadone dosage.
    • Subjective drug effects paralleled the observed performance decrements.
    • Visual evoked potentials showed alterations at peak drug effect.

    Conclusions:

    • Methadone depresses visual function, likely by acting on central nervous system visual pathways.
    • Potential sites of action include the retina, midbrain, and thalamic visual nuclei.
    • The findings clarify the impact of methadone on visual processing and reaction time.