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Related Experiment Videos

Basophilic leucocytes: structure, function and role in disease.

H F Dvorak, A M Dvorak

    Clinics in Haematology
    |October 1, 1975
    PubMed
    Summary
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    Human basophils, once neglected, are now understood to release mediators involved in allergic reactions. Their precise roles in health and disease, particularly in homeostasis via gradual mediator release, require further investigation.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Basophils (a type of white blood cell) were historically understudied.
    • Recent research has significantly advanced understanding of basophil morphology, biochemistry, and functions.

    Purpose of the Study:

    • To review current knowledge on human basophils and their functions.
    • To explore the potential roles of basophils and mast cells in homeostasis and disease.

    Main Methods:

    • Review of experimental data, including animal studies.
    • Analysis of recent findings on basophil interactions, mediator release, and degranulation.

    Main Results:

    • Basophils interact with antibodies, release mediators in anaphylaxis, respond to chemotaxis, and degranulate in hypersensitivity reactions.

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  • A hypothesis suggests basophils and mast cells contribute to homeostasis through continuous, small-volume release of granule contents.

    • Conclusions:

    • The exact physiological roles of basophils and mast cells in health and disease remain unclear.
    • Further research is needed to elucidate the mechanisms of piecemeal degranulation and the physiological roles of granule components like histamine and heparin.