Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

beta2-Microglobulins.

M D Poulik, R A Reisfeld

    Contemporary Topics in Molecular Immunology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Beta2-microglobulin (B2M) protein shares sequence similarity with immunoglobulin constant regions and associates with HL-A antigens on nucleated cells. Its precise function remains unclear, but it interacts with complement and immune cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene.

    Oncogene·2013
    Same author

    Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer.

    British journal of cancer·2011
    Same author

    Biochemical and functional characterization of a new murine monoclonal antibody against human platelet glycoprotein IIIa.

    Platelets·2010
    Same author

    The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression.

    Oncogene·2009
    Same author

    DNA vaccines suppress angiogenesis and protect against growth of breast cancer metastases.

    Breast disease·2005
    Same author

    What to do with targeted IL-2.

    Drugs of today (Barcelona, Spain : 1998)·2003

    Area of Science:

    • Immunology
    • Molecular Biology
    • Biochemistry

    Background:

    • A low-molecular-weight protein, beta2-mu, was isolated from biological fluids.
    • Its amino acid sequence shows homology to the CH3 constant region of immunoglobulin heavy chains.
    • Homologues of beta2-mu were also identified and partially sequenced.

    Purpose of the Study:

    • To investigate the structural and functional properties of beta2-mu.
    • To determine the cellular localization and associations of beta2-mu.
    • To explore the potential immunological roles of beta2-mu.

    Main Methods:

    • Protein isolation and partial sequencing.
    • Cellular localization studies.
    • Immunological assays including complement binding and cytophilic activity.

    Related Experiment Videos

  • Antibody-mediated functional assays (mitogenesis, mixed lymphocyte cultures).

    • Main Results:

    • Beta2-mu is localized in the membranes of nucleated cells and associated with Human Leukocyte Antigen (HLA) class I antigens.
    • The protein binds complement and exhibits cytophilic properties for guinea pig macrophages and other cells.
    • Antibodies against beta2-mu can function as mitogens and inhibit mixed lymphocyte cultures (MLCs) but not "killer" lymphocyte recognition.

    Conclusions:

    • Beta2-mu is structurally related to immunoglobulins and associated with cell surface antigens.
    • It possesses biological activities involving complement and cellular interactions.
    • Its role in immune responses, particularly T-cell activation and cytotoxicity, warrants further investigation.