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Hyperosmolar non-ketotic diabetic coma: with particular reference to vascular complications
British Medical Journal
|January 9, 1971
Summary
Hyperosmolar non-ketotic diabetic coma can lead to fatal mesenteric thrombosis and intestinal infarction. Vascular thromboses are a critical complication requiring consideration in patients presenting with acute abdominal symptoms.
Area of Science:
- Internal Medicine
- Gastroenterology
- Endocrinology
Background:
- Hyperosmolar non-ketotic diabetic coma is a serious diabetic complication.
- Intra-abdominal catastrophes can occur in patients with diabetic emergencies.
Purpose of the Study:
- To highlight the association between hyperosmolar non-ketotic diabetic coma and mesenteric thrombosis.
- To emphasize the importance of considering vascular complications in these patients.
Main Methods:
- Case report of two patients with no prior history of diabetes mellitus.
- Clinical presentation, management, and necropsy findings were analyzed.
Main Results:
- Both patients developed hyperosmolar non-ketotic diabetic coma.
- Mesenteric thrombosis leading to intestinal infarction was implicated in their deaths.
- Vascular thromboses were confirmed at necropsy.
Conclusions:
- Vascular thromboses, particularly mesenteric thrombosis, are a significant complication of hyperosmolar non-ketotic diabetic coma.
- Acute abdominal signs in these patients warrant thorough investigation for vascular catastrophes.