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Furazolidone in paediatric cholera
Bulletin of the World Health Organization
|January 1, 1970
Summary
Furazolidone is a viable alternative to tetracycline for treating cholera in children. This study found furazolidone effective in reducing diarrhea symptoms, though slightly less so in decreasing bacterial shedding.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pediatrics
Background:
- Tetracycline is a standard cholera treatment but faces challenges like cost, shelf-life, and emerging bacterial resistance.
- Alternative antimicrobial agents are needed for effective cholera management.
Purpose of the Study:
- To evaluate furazolidone as an alternative antimicrobial agent for treating cholera in children.
- To compare the efficacy of furazolidone with tetracycline in reducing diarrhea and bacterial excretion.
Main Methods:
- Clinical trial comparing furazolidone and tetracycline in children with classical cholera.
- Assessment of diarrhea volume, duration, and Vibrio cholerae excretion duration.
Main Results:
- Furazolidone demonstrated comparable efficacy to tetracycline in reducing diarrhea volume and duration in children.
- A 7-day course of antimicrobial therapy showed slightly less effectiveness in reducing vibrio excretion duration with furazolidone.
- Undernourished children exhibited a diminished response to antimicrobial therapy.
Conclusions:
- Furazolidone presents a reasonable and effective alternative to tetracycline for pediatric cholera treatment.
- Antimicrobial therapy duration may influence vibriocidal antibody response, particularly in younger children.