Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An instrument for stable single cell recording from pulsating human cerebral cortex.

S R Goldstein, M J Bak, J C Oakley

    Electroencephalography and Clinical Neurophysiology
    |December 1, 1975
    PubMed
    Summary

    A new instrument precisely positions microelectrodes on the pulsating brain surface. This enables stable, long-term single neuron recordings from the human cerebral cortex.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Presidential reflections: how we got here, where we might go.

    Climacteric : the journal of the International Menopause Society·2023
    Same author

    Reply.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
    Same author

    Skin, hair and beyond: the impact of menopause.

    Climacteric : the journal of the International Menopause Society·2022
    Same author

    Reaffirming microcystic ultrasound appearance of borderline ovarian tumors using three-dimensional 'silhouette' rendering.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
    Same author

    Bone health 2022: an update.

    Climacteric : the journal of the International Menopause Society·2022
    Same author

    Update on bone health: the International Menopause Society White Paper 2021.

    Climacteric : the journal of the International Menopause Society·2021

    Area of Science:

    • Neurosurgery
    • Neuroscience
    • Biomedical Engineering

    Background:

    • Accurate neuronal recording is crucial for understanding brain function.
    • Existing methods face challenges with brain pulsation and movement.
    • Precise electrode placement is difficult in dynamic neural environments.

    Purpose of the Study:

    • To develop and evaluate a novel instrument for stable microelectrode positioning.
    • To overcome challenges posed by the pulsating cerebral cortex.
    • To enable reliable extracellular single-cell recordings from the brain surface.

    Main Methods:

    • Development of a specialized instrument for microelectrode guidance.
    • Integration of electrode movement with cortical pulsation.
    • Testing the instrument on an exposed human brain during surgery.

    Related Experiment Videos

    Main Results:

    • The instrument successfully maintained a fixed relationship between the electrode and target neurons.
    • Stable extracellular single-cell recordings were achieved for 17.5 minutes.
    • The system compensated for 1.5 mm of surface pulsation on the human cerebral cortex.

    Conclusions:

    • The developed instrument significantly improves the stability of microelectrode recordings.
    • This technology facilitates high-fidelity neural signal acquisition from the pulsating brain.
    • It holds potential for advancing neurophysiological research and brain-computer interfaces.