Related Experiment Video
Updated: Aug 5, 2026

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
Published on: July 3, 2016
Equilibrium under inbreeding in balanced polymorphisms
Abstract:
The results of a study on frequencies of genes causing lethal or sublethal disease are reported in relation to the level of consanguinity and heterozygote advantage in populations. The theoretical background of the population dynamics of genes under heterozygote advantage and in the presence of inbreeding is examined and the theoretical models are applied to the estimation of the level of heterosis for lethal and sublethal genes that are responsible for important public health problems in certain populations; these problems include beta-thalassaemia and sickle-cell anaemia. Estimates obtained from the proposed models show a high degree of internal consistency under widely different conditions; data on sickle-cell anaemia from several African populations and on beta-thalassaemia from Italy and Malta were analysed. The hypothesis that rare lethal genes, such as those for Tay-Sachs disease, are maintained in the human population by heterozygote advantage is examined and discussed.
Related Concept Videos
Hardy-Weinberg Principle
Law of Segregation
Law of Independent Assortment
Law of Independent Assortment
Chi-square Analysis
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
Incomplete Dominance

