The Kallmann syndrome

The endocrinologic status of three patients with the Kallmann syndrome and anosmia were studied. Other than hypogondotropic hypogonadism, no abnormalities were found. Although the testosterone response to human chorionic gonadotropin was normal in all three patients, none of them responded to the antiestrogen, clomiphene. These patients are compared to others from the literature and it is concluded that the Kallmann syndrome is a heterogeneous category, comprising a number of clinically and genetically distinct disorders.