Related Experiment Videos
HLA-B7 in presumed ocular histoplasmosis maculopathy
Transplantation Proceedings
|December 1, 1979
Summary
Presumed ocular histoplasmosis syndrome (POHS) is linked to the HLA-B7 antigen. While statistically significant, other factors likely contribute to POHS development.
Area of Science:
- Ophthalmology
- Immunogenetics
Background:
- Presumed ocular histoplasmosis syndrome (POHS) is an idiopathic condition.
- POHS is characterized by specific clinical findings including peripheral atrophic scars and macular lesions.
Purpose of the Study:
- To investigate the association between human leukocyte antigen (HLA) types and POHS.
- To determine if specific histocompatibility antigens are more prevalent in patients with POHS.
Main Methods:
- Human leukocyte antigen (HLA) typing was performed on 64 patients meeting clinical criteria for POHS.
- Clinical criteria included peripheral choroidal atrophic scars, clear vitreous, and macular disciform lesions.
Main Results:
- A statistically significant association was found between POHS and the HLA-B7 antigen (p < 0.005).
- Thirty-four out of 64 patients possessed the HLA-B7 antigen.
Conclusions:
- The HLA-B7 antigen may play a role in the pathogenesis of POHS.
- The association is statistically significant but does not fully explain POHS, suggesting other genetic or environmental factors are involved.