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[Effect of anticholinergics on bladder tonus and on the voiding function].
Zeitschrift Fur Urologie Und Nephrologie
|October 1, 1979
Summary
Peripheral anticholinergic drugs selectively impact the urinary bladder, increasing its capacity. These medications reduce voiding pressure and urine flow rate while enhancing urethral pressure, aiding bladder disease treatment.
Area of Science:
- Pharmacology
- Urology
Background:
- Anticholinergic drugs are used to treat various medical conditions.
- Selective peripheral action on the urinary bladder is a key characteristic.
Purpose of the Study:
- To investigate the effects of peripheral anticholinergic drugs on specific urinary bladder parameters.
- To determine the clinical applicability of these drugs in treating bladder diseases.
Main Methods:
- The study evaluated the effects of anticholinergic drugs on urinary bladder capacity, intravesical pressure, and urethral pressure.
- Measurements included intravesical pressure during filling and micturition, urine flow rate, and urethral pressure.
Main Results:
- Increased urinary bladder capacity was observed.
- No significant change in intravesical pressure at maximum filling.
- Decreased maximum intravesical pressure during micturition and reduced urine flow rate.
- Increased maximum urethral pressure with no change in functional urethral length.
Conclusions:
- Peripheral anticholinergic drugs demonstrate specific effects on bladder function.
- These drugs show potential for effective treatment of certain urinary bladder diseases with appropriate indications.