Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bufotenine esters.

R A Glennon, P K Gessner, D D Godse

    Journal of Medicinal Chemistry
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Bufotenine esters show high affinity for serotonin receptors, suggesting they may bypass the blood-brain barrier limitations of bufotenine. These novel compounds offer potential for future pharmacological research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Structural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters.

    ACS chemical neuroscience·2015
    Same author

    Stereoselective Actions of Methylenedioxypyrovalerone (MDPV) To Inhibit Dopamine and Norepinephrine Transporters and Facilitate Intracranial Self-Stimulation in Rats.

    ACS chemical neuroscience·2015
    Same author

    Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues.

    British journal of pharmacology·2014
    Same author

    Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues.

    British journal of pharmacology·2014
    Same author

    Abuse-related and abuse-limiting effects of methcathinone and the synthetic "bath salts" cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats.

    Psychopharmacology·2013
    Same author

    Interspecies differences in the metabolism of brain norepinephrine to glycol metabolites.

    Neurochemistry international·2010
    Same journal

    Library Docking for Cannabinoid-2 Receptor Ligands.

    Journal of medicinal chemistry·2026
    Same journal

    Charting New Territory: Systematic Evaluation of the Drug Potential of <i>N</i>-Trifluoromethyl Amides, Ureas & Carbamates.

    Journal of medicinal chemistry·2026
    Same journal

    Red-Light-Triggered <i>In Vitro</i> and <i>In Vivo</i> Photocatalytic Cancer Therapy with Polypyridyl Os(II) Photocatalysts.

    Journal of medicinal chemistry·2026
    Same journal

    Novel Selenium-Containing Small Molecule PD-L1 Inhibitors: Design, Synthesis, and Evaluation of the Antitumor Activity.

    Journal of medicinal chemistry·2026
    Same journal

    HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy.

    Journal of medicinal chemistry·2026
    Same journal

    Rational Development of Activatable Prodrugs of the GSTP1 Inhibitor NBDHEX: Turn-On NIR Fluorogenic Drug Delivery with Selective Anticancer Activity.

    Journal of medicinal chemistry·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Medicinal Chemistry

    Background:

    • Bufotenine (5-hydroxy-N,N-dimethyltryptamine) exhibits limited behavioral activity in humans and animals.
    • This inactivity is potentially due to its low partition coefficient, hindering blood-brain barrier penetration.

    Purpose of the Study:

    • To synthesize bufotenine esters for pharmacological evaluation.
    • To investigate the potential of bufotenine derivatives to overcome the pharmacokinetic limitations of the parent compound.

    Main Methods:

    • Synthesis of acetyl, propionyl, butyryl, isobutyryl, and pivalyl esters of bufotenine.
    • Assessment of ester affinity for serotonin receptors using an isolated rat stomach fundus preparation.
    • Chromatographic analysis to evaluate ester hydrolysis rates.

    Related Experiment Videos

    Main Results:

    • All synthesized bufotenine esters demonstrated significant affinity for serotonin receptors.
    • Limited hydrolysis of the esters to bufotenine was observed under assay conditions, indicating ester stability.

    Conclusions:

    • Bufotenine esters possess high affinity for serotonin receptors, independent of bufotenine's central nervous system penetration.
    • These novel esters represent promising candidates for further pharmacological investigation and potential therapeutic development.